THE EFFICACY AND SAFETY OF ICOTINIB IN PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER PREVIOUSLY TREATED WITH CHEMOTHERAPY: A SINGLE-ARM, MULTI-CENTER, PROSPECTIVE STUDY.

Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows Course a pied - Accessoires - Nutrition - Jujubes non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial.The present study was designed to further evaluate the efficacy and safety of icotinib in patients with adva

The paper studies a plane four-bar mechanism in a dead, kinematically indeterminate position.From that position, the mechanism could continue to move, continuously, or the driven lever would stop and move EFALEX backwards.But, if we eliminate this second possibility, the position of the mechanism is no longer indeterminate and it would be logical t

The widespread incidence of cardiovascular diseases and associated mortality and morbidity, along with the advent of powerful computational resources, have fostered an extensive research in computational modeling of vascular pathophysiology field and promoted in-silico models as a support for biomedical research.Given the multiscale nature of biolo

Background: Depression is the largest source of global medical disability, highlighting the importance of translating and validating depression screening instruments to improve our understanding of differences in the prevalence of depression in divergent cultures around the world.The aim of this study was to translate and evaluate a widely used dep

To solve the problems of untimely and low accuracy of tunnel project collapse risk prediction, this study proposes a method of multi-source information fusion.The method uses the PSO-SVM model to predict the Lint Roller surrounding rock displacement.With the prediction index as the benchmark, the Cloud Model (CM) is used to calculate the basic prob